Type 1: Type 1 tumours (approximately 80% of total) are usually sessile polyps and associated with (usually autoimmune) atrophic gastritis, pernicious anaemia, achlorhydria and hypergastrinaemia, with the elevated gastrin being produced by gastric antral G cells.
Type 2 gastric NETs (approximately 5% of total) occur in patients with Zollinger Ellison syndrome, usually in the setting of multiple endocrine neoplasia type 1 (MEN1). They are therefore associated with gastrinomas, hypergastrinaemia and gastric hyperacidity.
Type 3 gastric NETs (approximately 15%) occur sporadically and are not associated with hypergastrinaemia
| Well-differentiated neuroendocrine neoplasms (NENs) | ||
| Ki-67 index (%) | Mitotic index/10 HPF | |
| NET grade 1 (G1) | < 3 | < 2 |
| NET grade 2 (G2) | 3-20 | 2-20 |
| NET grade 3 (G3) | > 20 | > 20 |
| Poorly differentiated neuroendocrine neoplasms (NENs) | ||
| Ki-67 index (%) | Mitotic index/10 HPF | |
| NEC grade 3 | >20 | >20 |
Goddard AF, Badreldin R, Pritchard DM on behalf of the British Society of Gastroenterology, et al The management of gastric polyps Gut 2010;59:1270-1276
Delle Fave et al. ENETS Consensus Guidelines for the Management of patients with Gastroduodenal Neoplasms. Neuroendocrinology 2012;95:74–87. DOI: 10.1159/000335595
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