Lynch surveillance

  Colonoscopy, Oncology

Lynch syndrome (HNPCC) surveillance: European Society of Gastrointestinal Endoscopy (ESGE) recommendations

-ESGE recommends starting colonoscopy surveillance at
the age of 25 years for MLH1 and MSH2 mutation carriers
and at the age of 35 years for MSH6 and PMS2 mutation

-ESGE recommends a high quality surveillance colonoscopy
every 2 years in asymptomatic individuals with Lynch

-ESGE does not recommend routine gastric surveillance in
individuals with Lynch syndrome.

-ESGE suggests (non-invasive) testing for Helicobacter
pylori in individuals with Lynch syndrome.

-Transvaginal ultrasound every 2 years from 40-60 years

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Fap vs Lynch
Polyposis syndromes


Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Giardiello, Francis M MD1; Allen, John I2; Axilbund, Jennifer E1; Boland, Richard C3; Burke, Carol A4; Burt, Randall W5; Church, James M4; Dominitz, Jason A6, 7; Johnson, David A8; Kaltenbach, Tonya9; Levin, Theodore R10; Lieberman, David A11; Robertson, Douglas J12, 13; Syngal, Sapna14, 15, 16; Rex, Douglas K17 Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer, American Journal of Gastroenterology: August 2014 – Volume 109 – Issue 8 – p 1159-1179 doi: 10.1038/ajg.2014.186

STOET stichting opsporing erfelijke tumoren