Pancreatic cancer ranks the 11th most common cancer in the world counting 458,918 new cases and 432,242 deaths in 2018. Worldwide incidence and mortality of pancreatic cancer increases with age, occurring moderately more often in in men than in women. Risk factors include cigarette smoking and family history. Two types of pancreatic cancer occur: pancreatic adenocarcinoma, around 85%, arising from the exocrine glands of the pancreas, and pancreatic neuroendocrine tumor, less than 5%, and occurs in the endocrine tissue of the pancreas. Pancreatic adenocarcinoma has a very poor prognosis with a 1-year survival of 24% and a 5-year survival of 9%. Cases eligible for resection have a 5-year survival of around 20%. Without treatment the median survival is 4 to 6 months.
-Abdominal CT scan with a early portal phase and portal vein phase
-Optional: Endoscopic ultrasound to obtain tissue (if CT is inconclusive or the pancreatic cancer is potentially resectable).
-Lab: CA19-9, CEA, evt IgG4
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA,
Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394424.