Cumulative risk of main outcomes on Left sided Ulcerative Colitis phenotype, disease activity and Colorectal Cancer.
Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review.
Results taken from the abstract of the article
Left-sided colitis is the most frequent location, and disease extension is observed in 10%–30% of patients. Majority of patients have a mild-moderate course, which is most active at diagnosis and then in varying periods of remission or mild activity; about 10%–15% of patients experience an aggressive course, and the cumulative risk of relapse is 70%–80% at 10 years. Almost 50% of patients require UC-related hospitalization, and 5-year risk of re-hospitalization is ∼50%. The 5-year and 10-year cumulative risk of colectomy is 10%–15%; achieving mucosal healing is associated with lower risk of colectomy. About 50% of patients receive corticosteroids, although this proportion has decreased over time, with a corresponding increase in the use of immunomodulators (20%) and anti–tumor necrosis factor (5%–10%). Although UC is not associated with an increased risk of mortality, it is associated with high morbidity and work disability, comparable to Crohn’s disease.
Ulcerative Colitis: Disease Recurrence in a European-wide Population-Based Cohor
Conclusion: In 67% of patients, there was at least one relapse. Smoking status, level of education, and possibly female gender were found to influence the risk of relapse
Fumery M, Singh S, Dulai PS, Gower-Rousseau C, Peyrin-Biroulet L, Sandborn WJ. Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review. Clin Gastroenterol Hepatol. 2018;16(3):343-356.e3. doi:10.1016/j.cgh.2017.06.016
Höie O, Wolters F, Riis L, et al. Ulcerative colitis: patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort. Am J Gastroenterol. 2007;102(8):1692-1701. doi:10.1111/j.1572-0241.2007.01265.x