IBD, Ulcerative Colitis

Several diagnostic and treatment algorithms for pouchitis

Pouchitis disease activity index:

Pouchitis disease activity index

Pouchitis diagnostic algorithm Shen 2013 Clin Gastroenterol Hepatol.

Pouchitis treatment algorithm. Shen 2013 Clin Gastroenterol Hepatol.

Alternative treatment algorithm (reference?)

Segal et al. Systematic Review With Meta-Analysis: The Management of Chronic Refractory Pouchitis With an Evidence-Based Treatment Algorithm. Aliment Pharmacol Ther Actions 2017

Nguyen et al. Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. Cochrane Database of Systematic Reviews 2019

Author’s conclusions:

The effects of antibiotics, probiotics and other interventions for treating and preventing pouchitis are uncertain. Well designed,
adequately powered studies are needed to determine the optimal therapy for the treatment and prevention of pouchitis.


Segal JP, Ding NS, Worley G, et al. Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm [published correction appears in Aliment Pharmacol Ther. 2018 Mar;47(6):864]. Aliment Pharmacol Ther. 2017;45(5):581-592.

Shen B. Pouchitis: what every gastroenterologist needs to know. Clin Gastroenterol Hepatol. 2013;11(12):1538-1549. doi:10.1016/j.cgh.2013.03.033