Work-up anal carcinoma: -Rectoscopy with biopsies -MRI -Optional: Endoscopy ultrasound to inspect transmural invasion. -Optional: FDG-PET could be useful for stage evaluation and for a radiation plan. Treatment anal carcinoma based on stage: Tis: -Anal Intraepithelial Neoplasia (AIN): yearly check -AIN 2/3: treatment with electro- or infraredcoagulation. -Peri-anal AIN 2/3: Imiquimod cT1N0: -Curative surgery 1 ..

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